Greenough A, Hird M F, Everett L, Price J F
Department of Child Health, King's College Hospital, London, England.
Pediatr Pulmonol. 1991;11(3):207-11. doi: 10.1002/ppul.1950110305.
Functional residual capacity (FRC) can be assessed reliably in young children using a helium gas dilution technique. The aim of the present study was to determine if differences in lung volume are found in asthmatic children of different ethnic origins. Eighty-eight children were studied, 53 of Caucasian origin and 35 of Afro-Caribbean origin. Their median age was 6.1 years (range, 5.3-9.0 years). FRC measured by helium gas dilution is reported as a percentage of predicted for height, using a published regression equation as well as regression equations appropriate for the ethnic origin of the child. In the majority of both groups FRC was elevated above the ethnically appropriate regression equation for healthy children. The Caucasian children apparently had higher FRCs than the Afro-Caribbean children if comparing the absolute lung volume, and if lung volume was expressed as percent of predicted for height, by a regression equation uncorrected for ethnic origin (P less than 0.02). This difference disappeared when ethnically appropriate regression equations were used. We conclude that lung volumes are similar in asthmatic children of different ethnic origin and that it is important to use ethnically appropriate regression equations.
使用氦气稀释技术可以可靠地评估幼儿的功能残气量（FRC）。本研究的目的是确定不同种族来源的哮喘儿童在肺容量上是否存在差异。研究了88名儿童，其中53名是白种人，35名是非洲裔加勒比人。他们的中位年龄为6.1岁（范围5.3 - 9.0岁）。通过氦气稀释测量的FRC以相对于身高预测值的百分比形式报告，使用已发表的回归方程以及适合儿童种族来源的回归方程。在两组中的大多数儿童中，FRC高于适合健康儿童种族的回归方程。如果比较绝对肺容量，并且如果肺容量以相对于身高预测值的百分比形式表示，使用未针对种族来源进行校正的回归方程时，白种儿童的FRC明显高于非洲裔加勒比儿童（P小于0.02）。当使用适合种族的回归方程时，这种差异消失。我们得出结论，不同种族来源的哮喘儿童肺容量相似，并且使用适合种族的回归方程很重要。
