John B V, Chamilos G, Kontoyiannis D P
Clin Microbiol Infect. 2005 Jul;11(7):515-7. doi: 10.1111/j.1469-0691.2005.01170.x.
Zygomycosis is a rare but emerging mycosis. Because of the sub-optimal efficacy of the standard antifungal treatment for this disease, hyperbaric oxygen (HBO) has been used occasionally as an adjunctive therapeutic modality. A review of 28 published cases of zygomycosis indicates that adjunctive HBO may be beneficial in diabetic patients (94% survival), whereas its benefit in the small group of patients with haematological malignancies or bone marrow transplants is doubtful (33% survival; p 0.02). Prolonged courses of HBO were associated with a higher survival (100% survival; p 0.003). Additional studies are required to assess the optimal timing and dose for HBO treatment.
接合菌病是一种罕见但呈上升趋势的真菌病。由于针对该疾病的标准抗真菌治疗效果欠佳，高压氧（HBO）偶尔被用作辅助治疗手段。对28例已发表的接合菌病病例的回顾表明，辅助性HBO可能对糖尿病患者有益（生存率94%），而其对一小部分血液系统恶性肿瘤患者或骨髓移植患者的益处存疑（生存率33%；p<0.02）。较长疗程的HBO治疗与较高的生存率相关（生存率100%；p<0.003）。需要进一步研究以评估HBO治疗的最佳时机和剂量。
