Segal Eran, Menhusen Monty J, Shawn Simmons
General Intensive Care Unit, Department of Anesthesiology and Intensive Care, Sheba Medical Center, Tel Hashomer, Israel.
Isr Med Assoc J. 2007 May;9(5):355-7.
Invasive fungal infections by Mucorales or Aspergillus spp. are lethal infections in immune compromised patients. For these infections a multimodal approach is required. One potential tool for treating these infections is hyperbaric oxygen.
To evaluate the clinical course and utility of hyperbaric oxygen in patients with invasive fungal infections by Mucorales or Aspergillus spp.
We conducted a retrospective chart review of 14 patients treated with HBO as part of their multimodal therapy over a 12 year period.
Most patients had significant immune suppression due to either drug treatment or their underlying disorder. Thirteen of the 14 underwent surgery as part of the treatment and all were receiving antifungal therapy while treated with the hyperbaric oxygen. The number of HBO sessions ranged between 1 and 44. Seven of the patients survived the infection. No patient developed complications due to HBO therapy.
HBO is a potentially significant adjunct in the treatment of invasive fungal infections. Evidence on its usefulness as a standard of care in these infections is still lacking. Since it will be difficult to generate conclusive data regarding the importance of HBO in these infections, the value of HBO in these patients should be considered on an individual basis.
毛霉目或曲霉属真菌引起的侵袭性真菌感染在免疫功能低下的患者中是致命性感染。对于这些感染，需要采取多模式方法。高压氧是治疗这些感染的一种潜在工具。
评估高压氧在毛霉目或曲霉属真菌引起的侵袭性真菌感染患者中的临床病程及效用。
我们对14例在12年期间接受高压氧治疗作为其多模式治疗一部分的患者进行了回顾性病历审查。
大多数患者因药物治疗或基础疾病而有显著的免疫抑制。14例患者中有13例接受了手术作为治疗的一部分，并且在接受高压氧治疗时均接受抗真菌治疗。高压氧治疗疗程数在1至44次之间。7例患者感染后存活。没有患者因高压氧治疗出现并发症。
高压氧在侵袭性真菌感染的治疗中可能是一种重要的辅助手段。关于其作为这些感染的标准治疗方法有效性的证据仍然缺乏。由于难以获得关于高压氧在这些感染中重要性的确凿数据，应根据个体情况考虑高压氧在这些患者中的价值。
