阿扑吗啡和催产素诱导的雄性大鼠阴茎勃起与打哈欠：百日咳毒素的作用

Apomorphine- and oxytocin-induced penile erection and yawning in male rats: effect of pertussis toxin.

作者信息

Stancampiano R, Melis M R, Argiolas A

机构信息

B. B. Brodie Department of Neurosciences, University of Cagliari, Italy.

出版信息

Brain Res Bull. 1992 Feb;28(2):315-8. doi: 10.1016/0361-9230(92)90194-3.

DOI:10.1016/0361-9230(92)90194-3

PMID:1596750

Abstract

The effect of the intracerebroventricular (ICV) administration of pertussis toxin on penile erection and yawning induced by apomorphine and oxytocin was studied in male rats. Pertussis toxin (2 micrograms ICV) prevented the above behavioral responses to apomorphine (80 micrograms/kg SC) and oxytocin (30 ng ICV) on day 3 and 4, but not on day 0 and 1 after treatment. Oxytocin and apomorphine responses were restored on day 6. Similar results were obtained by microinjecting pertussis toxin (0.5 microgram) in the paraventricular nucleus of the hypothalamus, the most sensitive brain area for the induction of penile erection and yawning by oxytocin and apomorphine. The results suggest that G proteins are involved in the expression of above responses to apomorphine and oxytocin.

摘要

研究了在雄性大鼠中脑室内注射百日咳毒素对阿扑吗啡和催产素诱导的阴茎勃起及打哈欠的影响。百日咳毒素（2微克，脑室内注射）在处理后的第3天和第4天可预防对阿扑吗啡（80微克/千克，皮下注射）和催产素（30纳克，脑室内注射）的上述行为反应，但在处理后的第0天和第1天则无此作用。催产素和阿扑吗啡反应在第6天恢复。通过在下丘脑室旁核（对催产素和阿扑吗啡诱导阴茎勃起和打哈欠最敏感的脑区）微量注射百日咳毒素（0.5微克）也得到了类似结果。结果表明，G蛋白参与了对阿扑吗啡和催产素上述反应的表达。