一氧化氮合酶抑制剂可阻止雄性大鼠因阿扑吗啡和催产素诱导的阴茎勃起及打哈欠。
Nitric oxide synthase inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats.
作者信息
Melis M R, Argiolas A
机构信息
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
出版信息
Brain Res Bull. 1993;32(1):71-4. doi: 10.1016/0361-9230(93)90321-2.
The effect of NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine, two inhibitors of nitric oxide synthase, on apomorphine- and oxytocin-induced penile erection and yawning, was studied in male rats after intravenous and intracerebroventricular administration. Both compounds prevented dose-dependently apomorphine and oxytocin responses, when given systemically (5-50 mg/kg) or centrally (30-500 micrograms per rat), but NG-nitro-L-arginine methyl ester was about 5 times more potent than NG-monomethyl-L-arginine. The D-isomer of NG-monomethyl-L-arginine, which does not inhibit nitric oxide synthase, was ineffective. The results suggest that central nitric oxide is involved in the expression of penile erection and yawning induced by apomorphine and oxytocin.
在雄性大鼠静脉内和脑室内给药后，研究了两种一氧化氮合酶抑制剂NG-硝基-L-精氨酸甲酯和NG-单甲基-L-精氨酸对阿扑吗啡和催产素诱导的阴茎勃起及打呵欠的影响。当全身给药（5 - 50mg/kg）或中枢给药（每只大鼠30 - 500μg）时，这两种化合物均剂量依赖性地抑制阿扑吗啡和催产素反应，但NG-硝基-L-精氨酸甲酯的效力约为NG-单甲基-L-精氨酸的5倍。不抑制一氧化氮合酶的NG-单甲基-L-精氨酸的D-异构体无效。结果表明，中枢一氧化氮参与了阿扑吗啡和催产素诱导的阴茎勃起及打呵欠的表达。
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