Argiolas A, Melis M R, Vargiu L, Gessa G L
Eur J Pharmacol. 1987 Feb 10;134(2):221-4. doi: 10.1016/0014-2999(87)90168-3.
Intraventricular (i.c.v.) injection of d(CH2)5-Tyr(Me)-[Orn8]vasotocin, a potent oxytocin antagonist, antagonized in a dose-dependent manner (10-100 ng) penile erection and yawning induced by the systemic injection of apomorphine (80 micrograms/kg s.c.) or by the i.c.v. injection of oxytocin (30 ng). In contrast, the oxytocin antagonist, even at the dose of 10 micrograms, did not modify penile erection and yawning induced by the i.c.v. injection of ACTH-(1-24). These results suggest that apomorphine, but not ACTH-(1-24), induce penile erection and yawning by releasing oxytocin in some brain area.
向脑室内（i.c.v.）注射强效催产素拮抗剂d(CH2)5-Tyr(Me)-[Orn8]血管紧张素，以剂量依赖方式（10 - 100纳克）拮抗由皮下注射阿扑吗啡（80微克/千克）或脑室内注射催产素（30纳克）引起的阴茎勃起和打哈欠。相比之下，即使剂量为10微克，该催产素拮抗剂也不会改变由脑室内注射促肾上腺皮质激素（1 - 24）引起的阴茎勃起和打哈欠。这些结果表明，阿扑吗啡而非促肾上腺皮质激素（1 - 24）通过在某些脑区释放催产素诱导阴茎勃起和打哈欠。
