Ricardo Nágila M P S, Pinho Maria E N, Yang Zhuo, Attwood David, Booth Colin
Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 12200, CEP 60455-760 Fortaleza, Ceará, Brazil.
Int J Pharm. 2005 Aug 26;300(1-2):22-31. doi: 10.1016/j.ijpharm.2005.04.023.
Micellar solutions of EmPnEm copolymers may be mobile at ambient temperature and form hard gels on warming to body temperature, whereas micellar solutions of EmSnEm copolymers do not show this effect (E denotes oxyethylene, P oxypropylene and S oxyphenylethylene, and subscripts m and n denote chain lengths). The aim of this study was to combine the desirable gelation characteristics of solutions of the EmPnEm copolymers with the greater solubilising capacities of solutions of the EmSnEm copolymers. Accordingly, the gelation characteristics in aqueous solution of binary mixtures of the triblock copolymer E62P39E62 (Pluronic F87) with E137S18E137, E82S9E82 or E76S5E76 were investigated by rheological techniques. We have shown that 50/50 wt.% mixtures of E62P39E62 with either E137S18E137 or E82S9E82 at a total copolymer concentration of approximately 30 wt.% are fluids of low viscosity at temperature below 22-25 degrees C and gels of high elastic modulus at body temperature.The mixed systems have potential as vehicles for the controlled delivery of solubilised drug from gels formed in situ following subcutaneous injection of a low viscosity aqueous solution.
