Schreiber Wolfgang G, Morbach Andreas E, Stavngaard Trine, Gast Klaus K, Herweling Anette, Søgaard Lise Vejby, Windirsch Michael, Schmiedeskamp Jörg, Heussel Claus Peter, Kauczor Hans-Ulrich
Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University Medical School, Langenbeckstr. 1, 55131 Mainz, Germany.
Respir Physiol Neurobiol. 2005 Aug 25;148(1-2):23-42. doi: 10.1016/j.resp.2005.05.002.
Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this study was the assessment of potential sources of systematic errors of the ADC measurement. The influence of macroscopic motion was determined by measurements at two different delays after initiating the breath-hold, and before and after cardiac arrest. An intercentre comparison was performed in two age- and lung function-matched groups of lung-healthy volunteers at two research sites. Moreover, measurements of diffusion anisotropy were performed. We found no dependency of the ADC as a function of the delay after stop of inspiration. The influence of cardiac motion was less than 10%. In the intercentre comparison study, an excellent agreement between the two sites was found. First measurements of the diffusion tensor of intrapulmonary Helium-3 are shown.
超极化氦 - 3表观扩散系数（ADC）的磁共振成像技术是一种用于在体探测肺微观结构的新技术。本研究的目的是评估ADC测量中系统误差的潜在来源。通过在屏气开始后两个不同延迟时间以及心脏骤停前后进行测量，确定宏观运动的影响。在两个研究地点，对两组年龄和肺功能匹配的肺部健康志愿者进行了中心间比较。此外，还进行了扩散各向异性的测量。我们发现ADC与吸气停止后的延迟时间无关。心脏运动的影响小于10%。在中心间比较研究中，发现两个地点之间具有良好的一致性。展示了肺内氦 - 3扩散张量的首次测量结果。
