Dixon R S, Anderson R L, Hatt M U
Arch Ophthalmol. 1979 Nov;97(11):2147-50. doi: 10.1001/archopht.1979.01020020465012.
We observed substantial narrowing in 75% of fissures in patients with various types of lid retraction after topical application of aqueous 0.5% thymoxamine (moxisylyte). Even contralateral normal-appearing fissures in thyroid patients responded in this manner. The nonresponders in the lid retraction group included a patient with an orbital pseudotumor and patients with long-standing and stable euthyroid eye disease. No normal subjects' fissures responded greatly to thymoxamine. A substantial reduction in palpebral fissures was seen in all patients with thick extraocular muscles and in 14 of 18 (78%) of all fissures of thyroid patients; the average response was 2.3 mm. This effect may last for five hours after thymoxamine administration. Thymoxamine may be of use as a diagnostic test for thyroid eye disease, and if it can be modified to cause less ocular irritation, it may be beneficial in the medical treatment of eyelid retraction.
我们观察到，在局部应用0.5%的水合噻吗洛尔（莫西赛利）后，各类眼睑退缩患者中75%的睑裂明显变窄。即使是甲状腺疾病患者对侧外观正常的睑裂也有这种反应。眼睑退缩组中无反应者包括一名眼眶假瘤患者以及患有长期稳定的甲状腺功能正常眼病的患者。正常受试者的睑裂对噻吗洛尔无明显反应。所有眼外肌增厚的患者以及甲状腺疾病患者18条睑裂中的14条（78%）出现睑裂明显变窄；平均反应为2.3毫米。这种效应在给予噻吗洛尔后可能持续5小时。噻吗洛尔可用作甲状腺眼病的诊断试验，如果能对其进行改良以减少眼部刺激，可能对眼睑退缩的药物治疗有益。
