Haddad H M
New York Medical College, NY 10128, USA.
Metab Pediatr Syst Ophthalmol (1985). 1995;18(1-4):15-8.
This is a cumulative clinical study of the effect of topical guanethidine sulfate solution. Two hundred fifty-six cases of patients with lid retraction secondary to thyroid orbitopathy or trauma were treated with guanethidine sulfate 5-10% solution before surgical intervention was considered. Eighty-five percent of thyroid-related lid retraction responded to guanethidine sulfate, whereas only 67% of the traumatic or iatrogenic cases responded to guanethidine sulfate. None of the patients showed overt reaction to guanethidine sulfate. The conservative management of lid retraction with topical guanethidine sulfate is relatively safe and mostly effective and should be considered before surgical intervention is considered.
这是一项关于局部应用硫酸胍乙啶溶液效果的累积临床研究。在考虑手术干预之前，对256例继发于甲状腺眼眶病或外伤的眼睑退缩患者使用5%-10%的硫酸胍乙啶溶液进行治疗。85%的甲状腺相关眼睑退缩对硫酸胍乙啶有反应，而外伤性或医源性病例中只有67%对硫酸胍乙啶有反应。所有患者均未表现出对硫酸胍乙啶的明显反应。局部应用硫酸胍乙啶对眼睑退缩进行保守治疗相对安全且大多有效，在考虑手术干预之前应予以考虑。
