Bi Hong-yan, Na Jia, Zang Gui-ming, Zhang Wei, Yuan Yun
Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Jun 18;37(3):331.
Neurolymphomatosis (NL) is characterized by lymphomatous infiltration of the peripheral nervous system. We report a case of neurolymphomatosis (NL) which was confirmed by sural nerve biopsy. Sural nerve specimen from a 49-year-old female patient with weakness of limbs was examined with routine histochemical and immunohistochemistry staining, in which the first antibodies against CD3, CD20, CD45, CD45RO and CD68 were used. Numerous T-lymphoma cells invaded in the adipose tissue of epineurium of sural nerve. The nerve biopsy showed marked axonal degeneration of myelinated fibers. The clinical and histopathologic findings confirmed the diagnosis of neurolymphomatosis.
神经淋巴瘤（NL）的特征是外周神经系统出现淋巴瘤浸润。我们报告一例经腓肠神经活检确诊的神经淋巴瘤（NL）病例。对一名49岁肢体无力女性患者的腓肠神经标本进行常规组织化学和免疫组织化学染色检查，使用了抗CD3、CD20、CD45、CD45RO和CD68的一抗。大量T淋巴瘤细胞侵入腓肠神经外膜的脂肪组织。神经活检显示有髓纤维明显轴突变性。临床和组织病理学检查结果证实了神经淋巴瘤的诊断。
