van den Bent M J, de Bruin H G, Bos G M, Brutel de la Rivière G, Sillevis Smitt P A
Department of Neuro-oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
J Neurol. 1999 Dec;246(12):1159-63. doi: 10.1007/s004150050535.
Patients with non-Hodgkin's lymphoma occasionally develop widespread invasion of peripheral nerves by tumor cells or neurolymphomatosis (NL). Clinically this usually results in asymmetrical, progressive, and painful polyneuropathy. Diagnosis rests on the identification of tumor cells in peripheral nerves. To avoid false-negative biopsy findings in patients with malignant lymphomatous infiltration of peripheral nerves it has been recommended to biopsy clinically involved nerves. We present two patients with histologically confirmed NL in whom sural the nerve biopsy finding was negative despite clinical and neurophysiological evidence of involvement of the sural nerve a. The clinical features of NL are reviewed. Some patients with neurolyphomatosis have only focal or proximal involvement of nerves, requiring the biopsy of an affected part of these nerves. Magnetic resonance imaging may be useful in identifying affected nerves.
非霍奇金淋巴瘤患者偶尔会出现肿瘤细胞广泛侵犯周围神经或神经淋巴瘤（NL）。临床上，这通常导致不对称、进行性和疼痛性多发性神经病。诊断取决于在周围神经中识别肿瘤细胞。为避免周围神经恶性淋巴瘤浸润患者活检结果出现假阴性，建议对临床上受累的神经进行活检。我们报告了两名经组织学证实为NL的患者，尽管有临床和神经生理学证据表明腓肠神经受累，但腓肠神经活检结果为阴性。本文对NL的临床特征进行了综述。一些神经淋巴瘤患者仅存在神经的局灶性或近端受累，需要对这些神经的受累部位进行活检。磁共振成像可能有助于识别受累神经。
