[肺炎衣原体——钙化性主动脉瓣狭窄的一个新危险因素？]
[Chlamydia pneumoniae--a new risk factor for calcific aortic stenosis?].
作者信息
Kaden Jens J, Haghi Dariusch, Vocke Daniela C, Brueckmann Martina, Süselbeck Tim, Borggrefe Martin
机构信息
I. Medizinische Klinik, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim.
出版信息
Med Klin (Munich). 2005 Jun 15;100(6):334-9. doi: 10.1007/s00063-005-1042-0.
BACKGROUND
Nonrheumatic, calcific aortic stenosis is the main heart valve disease and the main cause of heart valve replacement in the elderly. Recent studies suggest that it is based on a chronic inflammatory process. The pathogenetic mechanisms, however, are unclear.
METHODS
A MEDLINE search was conducted for the phrases "chlamydia pneumoniae" and "aortic valve", and all articles published between 1966 and May 2004 were evaluated. Data presented as letter or congress abstract was also included.
RESULTS
Clinical and histopathologic studies demonstrate an association of calcific aortic stenosis and cardiovascular risk factors similar to atherosclerosis. As for atherosclerosis, infection with Chlamydia (C.) pneumoniae is also discussed as a further potential risk factor for calcific aortic stenosis. Previous seroepidemiologic and pathologic studies using various detection methods yielded heterogeneous results.
CONCLUSION
Thus, data suggesting a pathogenetic association of C. pneumoniae and calcific aortic stenosis should be interpreted cautiously.
背景
非风湿性、钙化性主动脉瓣狭窄是主要的心脏瓣膜疾病，也是老年人心脏瓣膜置换的主要原因。近期研究表明，它基于一种慢性炎症过程。然而，其发病机制尚不清楚。
方法
在MEDLINE数据库中检索“肺炎衣原体”和“主动脉瓣”相关词组，并对1966年至2004年5月发表的所有文章进行评估。以信函或会议摘要形式呈现的数据也被纳入。
结果
临床和组织病理学研究表明，钙化性主动脉瓣狭窄与心血管危险因素之间存在关联，类似于动脉粥样硬化。与动脉粥样硬化一样，肺炎衣原体感染也被认为是钙化性主动脉瓣狭窄的另一个潜在危险因素。以往使用各种检测方法进行的血清流行病学和病理学研究结果各异。
结论
因此，对于提示肺炎衣原体与钙化性主动脉瓣狭窄之间存在发病学关联的数据应谨慎解读。
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