Andreasen J J, Farholt S, Jensen J S
Department of Cardiothoracic Surgery R, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
APMIS. 1998 Jul;106(7):717-20.
Chlamydia pneumoniae has been associated with atherosclerosis, although no causal association has been established. Employing culture and polymerase chain reaction in aortic valves with calcific and degenerative arteriosclerotic changes from 23 non-consecutive patients undergoing aortic valve replacement, C. pneumoniae was not detected in any of the valves. 19/22 patients had serological evidence of past infection with C. pneumoniae. Our findings do not provide supportive evidence for the hypothesis that C. pneumoniae is associated with calcific or degenerative arteriosclerotic aortic heart valve disease.
肺炎衣原体已被认为与动脉粥样硬化有关，尽管尚未确立因果关系。对23例接受主动脉瓣置换术的非连续患者的伴有钙化和退行性动脉硬化改变的主动脉瓣进行培养和聚合酶链反应检测，未在任何瓣膜中检测到肺炎衣原体。22例患者中有19例有既往肺炎衣原体感染的血清学证据。我们的研究结果不支持肺炎衣原体与钙化性或退行性动脉硬化性主动脉心脏瓣膜病有关的假说。
