Sweetman Dylan, Smith Terence G, Farrell Elizabeth R, Münsterberg Andrea
School of Biological Sciences, University of East Anglia, Norwich, UK.
Int J Dev Biol. 2005;49(4):427-30. doi: 10.1387/ijdb.051985ds.
The spalt family of transcriptional repressors has been implicated in limb, heart, ear and kidney development and truncating mutations in a human gene, SALL1, result in the autosomal dominant disorder Townes-Brocks syndrome. Here we show the expression pattern of the chick orthologue of the SALL1 gene, csal1, during early development. We found csal1 expression in the heart and in the pharynx, a source of inductive signals during heart development. Expression was also seen in involuting mesoderm and later in presegmented paraxial mesoderm. We also describe expression in the ectoderm and neural plate of the early embryo and subsequent expression in the neural tube.
转录抑制因子的spalt家族与肢体、心脏、耳朵和肾脏发育有关，人类基因SALL1中的截短突变会导致常染色体显性疾病汤姆斯综合征。在此，我们展示了SALL1基因的鸡直系同源基因csal1在早期发育过程中的表达模式。我们发现csal1在心脏和咽部表达，咽部是心脏发育过程中诱导信号的来源。在卷入的中胚层以及后来的预分割轴旁中胚层中也可见表达。我们还描述了其在早期胚胎外胚层和神经板中的表达以及随后在神经管中的表达。
