Albertazzi Paola
Centre for Metabolic Bone Disease, Hull Royal Infirmary, Hull, UK.
Gynecol Endocrinol. 2005 Jan;20(1):13-21. doi: 10.1080/09513590400020799.
Hot flushes are probably the most common symptom resulting in medical consultation in relation to the menopause and, when severe, they can affect quite dramatically women's quality of life. Hormone (estrogen) replacement therapy (HRT) is the most effective treatment for this symptom and in the ideal setting of clinical trials, under optimal selection of patients and compliance, it reduces hot flushes by about 70-80%. Recently, however, a series of 'scares' has had large resonance in the lay press about possible adverse effects of HRT. These have undermined both doctors' and women's confidence in the use of these compounds. This has been witnessed by the recent fall in HRT sales. A number of compounds, both pharmacological and herbal in origin, have been used for the treatment of neurovegetative symptoms in menopausal women. The present article critically reviews evidence of the efficacy of some of the most commonly used compounds and assesses their effect in relation to that of HRT.
潮热可能是导致更年期女性就医的最常见症状，严重时会极大地影响女性的生活质量。激素（雌激素）替代疗法（HRT）是治疗该症状最有效的方法，在理想的临床试验环境中，经过最佳的患者选择和依从性管理，它可使潮热减少约70%-80%。然而，最近一系列“恐慌”事件在大众媒体上引起了广泛反响，涉及HRT可能存在的不良反应。这些事件削弱了医生和女性对使用这些药物的信心。HRT销量最近的下降就证明了这一点。许多源自药理学和草药学的化合物已被用于治疗更年期女性的植物神经症状。本文对一些最常用化合物的疗效证据进行了批判性综述，并评估了它们相对于HRT的效果。
