Ogawa Yohei, Kikuchi Toru, Nagasaki Keisuke, Hiura Makoto, Tanaka Yukie, Uchiyama Makoto
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan.
Hypertens Res. 2005 Jan;28(1):51-7. doi: 10.1291/hypres.28.51.
This study aimed 1) to investigate the relationship between serum adiponectin levels and metabolic disorders and 2) to clarify the usefulness of serum adiponectin level as a diagnostic marker of metabolic syndrome in obese Japanese children. One hundred obese boys aged 8 to 13 years were examined. Serum adiponectin levels were measured by radioimmunoassay using a commercial kit. Abdominal fat thickness (maximum preperitoneal fat thickness: P(max); minimum subcutaneous fat thickness: S(min)) was measured by ultrasonography. The relationships between adiponectin and clinical characteristics were analyzed by simple regression. The relationships between anthropometric measurements and metabolic disorders were analyzed among three groups divided according to adiponectin percentile. The prevalence of metabolic syndrome was also analyzed, with metabolic syndrome defined as the presence of three or more complications of obesity. The criteria for metabolic syndrome by adiponectin were subjected to a receiver operating characteristic (ROC) analysis. Body weight, waist circumference, P(max), alanine aminotransferase and fasting serum insulin were all inversely correlated with adiponectin. There were significant differences in the prevalence of severe obesity, the accumulation of visceral adipose tissue, hyperinsulinemia, high serum low density lipoprotein-cholesterol, the number of complications of obesity and the prevalence of metabolic syndrome among the three groups. The area under the ROC curve for adiponectin was 0.672 +/- 0.055 and the cut-off value was 6.65 microg/ml. Hypoadiponectinemia was associated with visceral fat accumulation and metabolic syndrome in obese Japanese boys. Evaluation of adiponectin might contribute to an early intervention for obese children with metabolic syndrome.
1）调查血清脂联素水平与代谢紊乱之间的关系；2）阐明血清脂联素水平作为日本肥胖儿童代谢综合征诊断标志物的实用性。对100名8至13岁的肥胖男孩进行了检查。使用商用试剂盒通过放射免疫分析法测定血清脂联素水平。通过超声测量腹部脂肪厚度（最大腹膜前脂肪厚度：P（max）；最小皮下脂肪厚度：S（min））。通过简单回归分析脂联素与临床特征之间的关系。在根据脂联素百分位数划分 的三组中分析人体测量指标与代谢紊乱之间的关系。还分析了代谢综合征的患病率，代谢综合征定义为存在三种或更多肥胖并发症。对脂联素诊断代谢综合征的标准进行了受试者工作特征（ROC）分析。体重、腰围、P（max）、丙氨酸转氨酶和空腹血清胰岛素均与脂联素呈负相关。三组之间在重度肥胖患病率、内脏脂肪组织堆积、高胰岛素血症、高血清低密度脂蛋白胆固醇、肥胖并发症数量和代谢综合征患病率方面存在显著差异。脂联素的ROC曲线下面积为0.672±0.055，临界值为6.65微克/毫升。低脂联素血症与日本肥胖男孩的内脏脂肪堆积和代谢综合征相关。评估脂联素可能有助于对患有代谢综合征的肥胖儿童进行早期干预。
