Trøseid M, Lappegård K T, Mollnes T E, Arnesen H, Seljeflot I
Centre for Clinical Research, Ullevål University Hospital, Oslo, Norway.
Scand J Clin Lab Invest. 2005;65(4):283-90. doi: 10.1080/00365510510013811.
Inflammation plays an essential role in the atherosclerotic process. Cellular adhesion molecules (CAMs) such as E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are involved in the rolling, adhesion and extravasation of monocytes and T-lymphocytes into the atherosclerotic plaque. In the present study the effect of physical exercise and pravastatin (40 mg daily) on serum levels of CAMs and a possible role of adipose tissue in regulating serum levels of CAMs were investigated.
The study was designed as an unmasked randomized 2x2 factorial trial of 12 weeks duration in 32 subjects with the metabolic syndrome. Changes from baseline were studied, and correlations between changes in CAMs, anthropometric measures, regional fat distribution, glycaemic control and the adipocytokine tumour necrosis factor-a (TNF-a) and adiponectin were investigated.
No significant changes in CAMs were observed in any of the intervention groups. However, when examining the whole study population regardless of intervention, changes in serum E-selectin were significantly correlated to changes in body mass index (r=0.48, p=0.006), waist circumference (r=0.48, p=0.006), fasting glucose (r=0.43, p=0.02) and HbA1c (r=0.45, p=0.01), but not to changes in visceral fat, subcutaneous fat, TNF-a or adiponectin.
Changes in glycaemic control and obesity, rather than regional fat distribution, seem to influence the levels of E-selectin in subjects with the metabolic syndrome.
炎症在动脉粥样硬化过程中起重要作用。细胞黏附分子（CAMs），如E-选择素、细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1），参与单核细胞和T淋巴细胞向动脉粥样硬化斑块的滚动、黏附和外渗。在本研究中，调查了体育锻炼和普伐他汀（每日40毫克）对血清CAMs水平的影响以及脂肪组织在调节血清CAMs水平中的可能作用。
本研究设计为一项为期12周的非盲随机2×2析因试验，纳入32名患有代谢综合征的受试者。研究了与基线相比的变化，并调查了CAMs变化、人体测量指标、局部脂肪分布、血糖控制以及脂肪细胞因子肿瘤坏死因子-α（TNF-α）和脂联素之间的相关性。
在任何干预组中均未观察到CAMs有显著变化。然而，在不考虑干预情况检查整个研究人群时，血清E-选择素的变化与体重指数变化（r = 0.48，p = 0.006）、腰围变化（r = 0.48，p = 0.006）、空腹血糖变化（r = 0.43，p = 0.02）和糖化血红蛋白变化（r = 0.45，p = 0.01）显著相关，但与内脏脂肪、皮下脂肪、TNF-α或脂联素的变化无关。
血糖控制和肥胖的变化，而非局部脂肪分布，似乎会影响代谢综合征患者的E-选择素水平。
