[药物代谢酶在药物疗效及副作用中的作用]
[The role of drug metabolizing enzymes in the effect and side-effect of the drugs].
作者信息
Vereczkey László, Jemnitz Katalin, Monostory Katalin, Veres Zsuzsa, Kóbori László
机构信息
Magyar Tudományos Akadémia, Kémiai Kutatóközpont, Farmakobiokémiai Osztály, Budapest.
出版信息
Orv Hetil. 2005 May 8;146(19):947-52.
The authors give an overview on the role of drug metabolizing enzymes in the effect and side-effect of drugs. They describe the properties of cytochrome P450 and other phase I enzymes (hydrolases, flavin-monooxygenases), as well as of phase II. enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail.
作者对药物代谢酶在药物作用和副作用中的作用进行了概述。他们描述了细胞色素P450和其他I相酶（水解酶、黄素单加氧酶）以及II相酶（葡糖醛酸基转移酶、硫酸转移酶、谷胱甘肽转移酶、乙酰转移酶、甲基转移酶）的特性、它们的多态性、诱导和抑制特性。详细讨论了可能的药物相互作用。
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