细胞色素P450和含黄素单加氧酶的结构与功能：对药物代谢的影响

Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism.

作者信息

Halpert J R, Domanski T L, Adali O, Biagini C P, Cosme J, Dierks E A, Johnson E F, Jones J P, Ortiz de Montellano P, Philpot R M, Sibbesen O, Wyatt W K, Zheng Z

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, USA.

出版信息

Drug Metab Dispos. 1998 Dec;26(12):1223-31.

PMID:9860932

Abstract

This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.

摘要

本文是一篇关于在加利福尼亚州旧金山举行的“实验生物学98”研讨会上的报告。文中描述了细胞色素P450和含黄素单加氧酶在定点诱变、计算机建模以及机理分析方面的最新进展。一个统一的主题是阐述理解和预测这些酶的各个形式功能的通用方法。一个相关目标是制备用于X射线晶体学研究的可溶性哺乳动物细胞色素P450。