[促炎细胞因子在出生后早期个体发育过程中对行为形成的作用]
[The action of proinflammatory cytokines on formation of behavior during early postnatal ontogenesis].
作者信息
Zumareva O E, Eliseeva A P, Simbirtsev A S, Klimenko V M
出版信息
Ross Fiziol Zh Im I M Sechenova. 2005 Apr;91(4):374-84.
The study is devoted to the role of proinflammatory cytokine-interleukin-1beta during early postnatal ontogenesis in formation of behavioral programs. Cytokine was injected in pyrogenic and subpyrogenic doses during 1 week (1, 2 or 3 weeks of life). The behavior was tested in the young (40-45 days) and adult (3 months) rats in the "open field" and "elevated plus maze". The greatest behavior disordes (elevation of act's number and of motor activity, the decrease of investigation activity) are revealed in the young animals treated with IL-Ib during 1 and 3 weeks of life. These behavioral changes were marked in rats injected with pyrogenic and subpyrogenic doses of cytokine. They had a similar tendency in male and female rats. At the age of 3 months, behavior changes revealed in juvenile rats were insignificant.
这项研究致力于促炎细胞因子白细胞介素-1β在出生后早期个体发育过程中对行为程序形成的作用。在出生后1周（出生后1、2或3周）内，以致热剂量和亚致热剂量注射细胞因子。在“旷场”和“高架十字迷宫”中对幼年（40 - 45天）和成年（3个月）大鼠的行为进行测试。在出生后1周和3周接受IL-1β治疗的幼年动物中，发现了最严重的行为紊乱（行为次数和运动活动增加，探究活动减少）。这些行为变化在注射了致热剂量和亚致热剂量细胞因子的大鼠中均有明显表现。雄性和雌性大鼠有相似的趋势。在3个月大时，幼年大鼠出现的行为变化不明显。
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