Baksu A, Ayas B, Citak S, Kalan A, Baksu B, Goker N
1st Obstetrics and Gynecology Clinic, Sişli Etfal Training and Research Hospital, Istanbul, Turkey.
Int J Gynaecol Obstet. 2005 Oct;91(1):58-62. doi: 10.1016/j.ijgo.2005.04.011.
This study investigated the efficacy of tibolone and transdermal estradiol therapy on menopausal and psychological symptoms in women following surgical menopause.
Seventy-five women who had undergone surgical menopause were randomized to a 6-month double-blind interventional study treatment with oral 2.5 mg/day tibolone, transdermal 3.9 mg/week estradiol or oral placebo. The patients were assessed using Kupperman's Scale, Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) before and at the end of the 6 months of treatment.
Sixty-five subjects completed the study: 23 on tibolone, 21 on transdermal estradiol and 21 on placebo. At the end of the 6 months of therapy, highly significant improvements in menopausal symptoms, depression and anxiety scores were observed in both groups (tibolone and transdermal estradiol groups) as compared with baseline values (p<0.001). However, in the placebo group, there were no significant differences on changes from baseline to the end of treatment (p>0.05).
These results suggest that tibolone and transdermal estradiol therapy significantly improve menopausal and psychological symptoms in women following surgical menopause.
本研究调查替勃龙和经皮雌二醇疗法对手术绝经后女性更年期及心理症状的疗效。
75名经历手术绝经的女性被随机分配到一项为期6个月的双盲干预研究中，分别接受每日口服2.5毫克替勃龙、每周经皮3.9毫克雌二醇或口服安慰剂治疗。在治疗6个月前后，使用库珀曼量表、汉密尔顿抑郁评定量表（HDRS）和汉密尔顿焦虑评定量表（HARS）对患者进行评估。
65名受试者完成了研究：23人接受替勃龙治疗，21人接受经皮雌二醇治疗，21人接受安慰剂治疗。在6个月治疗结束时，与基线值相比，两组（替勃龙组和经皮雌二醇组）的更年期症状、抑郁和焦虑评分均有显著改善（p<0.001）。然而，在安慰剂组中，从基线到治疗结束的变化无显著差异（p>0.05）。
这些结果表明，替勃龙和经皮雌二醇疗法可显著改善手术绝经后女性的更年期及心理症状。
