Suneja R, Grimer R J, Belthur M, Jeys L, Carter S R, Tillman R M, Davies A M
The Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Birmingham B31 2AP, UK.
J Bone Joint Surg Br. 2005 Jul;87(7):974-8. doi: 10.1302/0301-620X.87B7.16009.
We undertook this retrospective study to determine the rate of recurrence and functional outcome after intralesional curettage for chondroblastoma of bone. The factors associated with aggressive behaviour of the tumour were also analysed. We reviewed 53 patients with histologically-proven chondroblastoma who were treated by intralesional curettage in our unit between 1974 and 2000. They were followed up for at least two years to a maximum of 27 years. Seven (13.2%) had a histologically-proven local recurrence. Three underwent a second intralesional curettage and had no further recurrence. Two had endoprosthetic replacement of the proximal humerus and two underwent below-knee amputation after aggressive local recurrence. One patient had the rare malignant metastatic chondroblastoma and eventually died. The mean Musculoskeletal Tumour Society functional score of the survivors was 94.2%. We conclude that meticulous intralesional curettage alone can achieve low rates of local recurrence and excellent long-term function.
我们开展这项回顾性研究,以确定骨软骨母细胞瘤行病灶内刮除术后的复发率和功能结局。同时分析了与肿瘤侵袭性行为相关的因素。我们回顾了1974年至2000年间在本单位接受病灶内刮除术治疗的53例经组织学证实的软骨母细胞瘤患者。对他们进行了至少两年、最长27年的随访。7例(13.2%)经组织学证实有局部复发。3例接受了第二次病灶内刮除术,未再复发。2例行肱骨近端假体置换,2例在局部侵袭性复发后行膝下截肢。1例患者患罕见的恶性转移性软骨母细胞瘤,最终死亡。幸存者的平均肌肉骨骼肿瘤学会功能评分是94.2%。我们得出结论,单纯细致的病灶内刮除术可实现较低的局部复发率和良好的长期功能。