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软骨母细胞瘤的治疗:28例患者的回顾性研究

Management of chondroblastoma: retrospective review of 28 patients.

作者信息

Atalar Hakan, Basarir Kerem, Yildiz Yusuf, Erekul Selim, Saglik Yener

机构信息

Department of Orthopaedic Surgery and Traumatology, Fatih University, Alparslan Turkes Caddesi No 57, 06510, Emek, Ankara, Turkey.

出版信息

J Orthop Sci. 2007 Jul;12(4):334-40. doi: 10.1007/s00776-007-1141-2. Epub 2007 Aug 2.

Abstract

BACKGROUND

This study retrospectively reviewed 28 patients who presented with chondroblastoma in our hospital during the period March 1986 to February 2006. We investigated factors associated with local recurrence of the tumors after surgery.

METHODS

We recorded the patients' sex and age, the location of the pathology, imaging studies (status of growth plate and activity of lesions), histological findings, and treatment outcomes.

RESULTS

Pain was the presenting symptom in all patients. The tumors were generally located in the epiphyses or apophyses of long bones, especially in the proximal humerus (9 patients), proximal tibia (7 patients), and proximal femur (5 patients). Our preferred treatment method was generally aggressive curettage of the lesion followed by bone grafting. There was local recurrence in six patients. A secondary aneurysmal bone cyst was present in two patients.

CONCLUSION

Aggressive curettage and bone grafting resulted in local control in most patients. Tumor recurrence was not statistically associated with age, sex, growth plate status, tumor location, or tumor activity. The only parameter associated with increased local recurrence was previous surgery for chondroblastoma in the same location.

摘要

背景

本研究回顾性分析了1986年3月至2006年2月期间我院收治的28例成软骨细胞瘤患者。我们调查了手术后肿瘤局部复发的相关因素。

方法

我们记录了患者的性别和年龄、病变部位、影像学检查结果(生长板状态和病变活性)、组织学检查结果以及治疗效果。

结果

所有患者均以疼痛为首发症状。肿瘤通常位于长骨的骨骺或骨突,尤其是肱骨近端(9例)、胫骨近端(7例)和股骨近端(5例)。我们首选的治疗方法通常是对病变进行积极的刮除,然后进行植骨。6例患者出现局部复发。2例患者存在继发性骨囊肿。

结论

积极的刮除和植骨使大多数患者实现了局部控制。肿瘤复发与年龄、性别、生长板状态、肿瘤位置或肿瘤活性无统计学关联。与局部复发增加相关的唯一参数是同一部位既往有过成软骨细胞瘤手术史。

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