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巴西混合人群中的谷胱甘肽S-转移酶M1(GSTM1)和T1(GSTT1)基因多态性

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in a Brazilian mixed population.

作者信息

Hatagima Ana, Marques Christiane F S, Krieger Henrique, Feitosa Mary F

机构信息

Departamento de Genética, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.

出版信息

Hum Biol. 2004 Dec;76(6):937-42. doi: 10.1353/hub.2005.0018.

DOI:10.1353/hub.2005.0018
PMID:15974302
Abstract

The GSTM1 and GSTT1 null genotype frequencies were significantly different between 658 nonblack and black healthy blood donors from a Brazilian mixed population (Rio de Janeiro). The GSTM1 phenotype distribution was not in Hardy-Weinberg equilibrium in either group, mainly because of an excess of the GSTM1*A/*B genotype.

摘要

在来自巴西混合人群(里约热内卢)的658名非黑人与黑人健康献血者中,谷胱甘肽S-转移酶M1(GSTM1)和谷胱甘肽S-转移酶T1(GSTT1)无效基因型频率存在显著差异。在两组中,GSTM1表型分布均不符合哈迪-温伯格平衡,主要原因是GSTM1*A/*B基因型过多。

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