Synthesis and ocular effects of imidazole nitrolic acids.

作者信息

Oresmaa Larisa, Kotikoski Hanna, Haukka Matti, Salminen Johanna, Oksala Olli, Pohjala Esko, Moilanen Eeva, Vapaatalo Heikki, Vainiotalo Pirjo, Aulaskari Paula

机构信息

Department of Chemistry, University of Joensuu, Joensuu, Finland.

出版信息

J Med Chem. 2005 Jun 30;48(13):4231-6. doi: 10.1021/jm048949+.

DOI:10.1021/jm048949+

PMID:15974576

Abstract

Novel 1-R-imidazole-2-nitrolic acids and 1-R-imidazole-5-nitrolic acids (R: H, Me, Bn) were synthesized from oximes by treatment with a mixture of fuming nitric acid and acetic acid. The effects of these potential nitric oxide-donating compounds were tested on ocular variables such as intraocular pressure and formation of cyclic guanosine-3,5'-monophosphate in the incubation of porcine iris-ciliary body.

摘要