Berezin Mikhail, Achilefu Samuel
Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, St. Louis, MO 63110, USA.
Tetrahedron Lett. 2007 Feb 12;48(7):1195-1199. doi: 10.1016/j.tetlet.2006.12.051.
The synthesized 1,3-dimethylated imidazolium carbaldehydes serves as synthons for incorporating a permanently cationic imidazolium group into molecular framework. The utility of new synthon was demonstrated in a variety of reactions: Knoevenagel, Wittig, Schiff base formation, based mediated electrophilic substitution and oxidation, including synthesis of the natural product norzooanemonin.
合成的1,3 - 二甲基咪唑鎓甲醛用作将永久性阳离子咪唑鎓基团引入分子骨架的合成子。这种新合成子的效用在多种反应中得到了证明：克诺文纳格尔反应、维蒂希反应、席夫碱形成反应、碱介导的亲电取代反应和氧化反应，包括天然产物去甲獐牙菜苦苷的合成。
