来自岛屿圣托里尼菊地上部分的细胞毒性吉马烷倍半萜。
Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.
作者信息
Appendino Giovanni, Aviello Gabriella, Ballero Mauro, Borrelli Francesca, Fattorusso Ernesto, Petrucci Francesca, Santelia Federico U, Taglialatela-Scafati Orazio
机构信息
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Italy.
出版信息
J Nat Prod. 2005 Jun;68(6):853-7. doi: 10.1021/np050120q.
Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.
对岛屿圣托里尼菊进行化学研究得到了11种吉马烷倍半萜（1-11），其中4种（2、3、10和11）为新化合物。这些化合物的立体结构已通过光谱技术（主要是核磁共振）、化学转化以及改良的莫舍尔方法的应用得以确定。化合物8和10对人结肠癌细胞系显示出强效且选择性的细胞毒性活性。
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