来自荨麻叶山香菊的吉马烷型倍半萜内酯

Germacranolides from Calea urticifolia.

作者信息

Yamada Masashi, Matsuura Nobuyasu, Suzuki Hiroto, Kurosaka Chihiro, Hasegawa Naoko, Ubukata Makoto, Tanaka Toshiyuki, Iinuma Munekazu

机构信息

Development Section, Pharmaceuticals Department, Meiji Milk Product Co. Ltd., 1-26-11 Midori, Shimada-ku, Tokyo 130-8502, Japan.

出版信息

Phytochemistry. 2004 Dec;65(23):3107-11. doi: 10.1016/j.phytochem.2004.08.040.

DOI:10.1016/j.phytochem.2004.08.040

PMID:15541738

Abstract

Four germacranolides, named calealactones A-C and calealactone B [corrected] were isolated from the leaves of Calea urticifolia (Compositae) in addition to three known germacranolides. Their structures were established on the basis of spectroscopic analysis including by 2D NMR spectroscopy. Calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells.

摘要

从荨麻叶牛膝菊（菊科）的叶子中分离出了四种吉马烷型倍半萜内酯，分别命名为牛膝菊内酯A - C和牛膝菊内酯B [校正]，此外还分离出了三种已知的吉马烷型倍半萜内酯。它们的结构是在光谱分析的基础上确定的，包括二维核磁共振光谱分析。牛膝菊内酯C和2,3 - 环氧胡安苏胺对U937细胞显示出强毒性。