Sitburana Oraporn, Koroshetz Walter J
Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622, USA.
Curr Atheroscler Rep. 2005 Jul;7(4):305-12. doi: 10.1007/s11883-005-0023-3.
Multimodality magnetic resonance imaging (MRI) techniques, including diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), fluid-attenuated inversion recovery (FLAIR), T2 susceptibility imaging, and magnetic resonance angiography (MRA), quickly provide accurate information about ischemic penumbra (DWI/PWI mismatch), tissue perfusion, and vascular localization in acute stroke setting. These techniques help physicians to select the proper candidates for thrombolysis and/or neuroprotective treatment to salvage tissue at risk (mismatch) and monitor acute stroke patients after treatment. Recent and ongoing trials demonstrate the benefit of treating acute stroke patients depending on tissue at risk of infarction rather than timing of onset. These techniques will extend timing to salvage ischemic brain tissue beyond the 3-hour window. MRI is a powerful tool for managing acute stroke patients and helps elucidate the pathophysiology of cerebral ischemia in a given patient.
多模态磁共振成像（MRI）技术，包括弥散加权成像（DWI）、灌注加权成像（PWI）、液体衰减反转恢复序列（FLAIR）、T2* 敏感性成像和磁共振血管造影（MRA），能在急性卒中情况下快速提供有关缺血半暗带（DWI/PWI不匹配）、组织灌注和血管定位的准确信息。这些技术有助于医生选择合适的溶栓和/或神经保护治疗候选者，以挽救处于危险中的组织（不匹配区域），并在治疗后监测急性卒中患者。近期和正在进行的试验表明，根据梗死风险组织而非发病时间来治疗急性卒中患者具有益处。这些技术将把挽救缺血脑组织的时间窗口延长至超过3小时。MRI是管理急性卒中患者的有力工具，有助于阐明特定患者脑缺血的病理生理学。
