饮食中组氨酸诱导厌食症的性别效应。
Gender effects in dietary histidine-induced anorexia.
作者信息
Kasaoka Seiichi, Kawahara Yumi, Inoue Setsuko, Tsuji Makiko, Kato Hideo, Tsuchiya Takahide, Okuda Hiromichi, Nakajima Shigeru
机构信息
Department of Health and Nutrition, Bunkyo University Women's College, Kanagawa, Japan.
出版信息
Nutrition. 2005 Jul-Aug;21(7-8):855-8. doi: 10.1016/j.nut.2004.12.009.
OBJECTIVE
Histamine, a derivative of histidine, decreases food intake by activation of histamine neurons. The aim of the present study was to clarify gender-related differences in food intake through the histidine-histamine neuron system.
METHODS
Male, female, and ovariectomized rats were fed a histidine-enriched diet or a control diet with the cafeteria method.
RESULTS
The suppressive effect of histidine on food intake was greater in female rats than in male rats, and the suppressive effect of histidine on food intake was less in ovariectomized rats than in female rats.
CONCLUSION
Our results indicate that females are more sensitive than males to dietary histidine-induced anorexia.
目的
组胺是组氨酸的衍生物，通过激活组胺神经元来减少食物摄入量。本研究的目的是阐明通过组氨酸-组胺神经元系统在食物摄入方面的性别差异。
方法
采用自助进食法，给雄性、雌性和去卵巢大鼠喂食富含组氨酸的饮食或对照饮食。
结果
组氨酸对雌性大鼠食物摄入的抑制作用大于雄性大鼠，且组氨酸对去卵巢大鼠食物摄入的抑制作用小于雌性大鼠。
结论
我们的结果表明，雌性比雄性对饮食中组氨酸诱导的厌食更敏感。
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