Li Yan-Chuan, Li Chun-Long, Qi Jia-Yue, Huang Li-Na, Shi Dan, Du Shan-Shan, Liu Li-Yan, Feng Ren-Nan, Sun Chang-Hao
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150086, China.
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Nutrients. 2016 Jul 11;8(7):420. doi: 10.3390/nu8070420.
Our previous studies have demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women and high-fat diet-induced obese rats. However, the effects of dietary histidine on general population are not known. The objective of this Internet-based cross-sectional study was to evaluate the associations between dietary histidine and prevalence of overweight/obesity and abdominal obesity in northern Chinese population. A total of 2376 participants were randomly recruited and asked to finish our Internet-based dietary questionnaire for the Chinese (IDQC). Afterwards, 88 overweight/obese participants were randomly selected to explore the possible mechanism. Compared with healthy controls, dietary histidine was significantly lower in overweight (p < 0.05) and obese (p < 0.01) participants of both sexes. Dietary histidine was inversely associated with body mass index (BMI), waist circumference (WC) and blood pressure in overall population and stronger associations were observed in women and overweight/obese participants. Higher dietary histidine was associated with lower prevalence of overweight/obesity and abdominal obesity, especially in women. Further studies indicated that higher dietary histidine was associated with lower fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-h postprandial glucose (2 h-PG), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), malonaldehyde (MDA) and vaspin and higher glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and adiponectin of overweight/obese individuals of both sexes. In conclusion, higher dietary histidine is inversely associated with energy intake, status of insulin resistance, inflammation and oxidative stress in overweight/obese participants and lower prevalence of overweight/obesity in northern Chinese adults.
我们之前的研究表明，补充组氨酸可显著改善肥胖女性和高脂饮食诱导的肥胖大鼠的炎症和氧化应激。然而，饮食组氨酸对普通人群的影响尚不清楚。这项基于互联网的横断面研究的目的是评估中国北方人群饮食组氨酸与超重/肥胖及腹型肥胖患病率之间的关联。总共随机招募了2376名参与者，并要求他们完成我们基于互联网的中文饮食问卷（IDQC）。之后，随机选择88名超重/肥胖参与者以探究可能的机制。与健康对照组相比，超重（p<0.05）和肥胖（p<0.01）的男女参与者饮食组氨酸均显著降低。饮食组氨酸与总体人群的体重指数（BMI）、腰围（WC）和血压呈负相关，在女性和超重/肥胖参与者中观察到更强的相关性。较高的饮食组氨酸与超重/肥胖及腹型肥胖的较低患病率相关，尤其是在女性中。进一步研究表明，较高的饮食组氨酸与超重/肥胖男女个体较低的空腹血糖（FBG）、胰岛素抵抗稳态模型评估（HOMA-IR）、餐后2小时血糖（2 h-PG）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、C反应蛋白（CRP）、丙二醛（MDA）和内脏脂肪素以及较高的谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和脂联素相关。总之，较高的饮食组氨酸与超重/肥胖参与者的能量摄入、胰岛素抵抗状态、炎症和氧化应激呈负相关，且与中国北方成年人较低的超重/肥胖患病率相关。
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