Duck Lionel, Devogelaer Jean-Pierre, Persu Alexandre, Berlière Martine, Caussin Emmanuelle, Baurain Jean-François, Machiels Jean-Pascal
Medical Oncology Unit, Centre du Cancer, Cliniques Universitaires St-Luc, Av. Hippocrate 10, 1200 Brussels, Belgium.
Gynecol Oncol. 2005 Aug;98(2):329-31. doi: 10.1016/j.ygyno.2005.05.014.
Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia.
A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. The diagnosis work-up revealed that she suffered from osteomalacia due to a chemotherapy-induced Fanconi syndrome. The patient recovered completely with oral calcitriol supplements.
This very rare chemotherapy-complication suggests that detection of potential tubular dysfunction, by regular serum electrolyte monitoring of patients receiving ifosfamide, may be a reasonable approach to diagnose early chemotherapy-induced Fanconi syndrome, even in adults.
