Selvendiran K, Prince Vijeya Singh J, Sakthisekaran D
Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.
Pulm Pharmacol Ther. 2006;19(2):107-11. doi: 10.1016/j.pupt.2005.04.002. Epub 2005 Jun 21.
In recent years, considerable emphasis has been focused on identifying new cancer chemopreventive agents, which could be useful for the human population. Piperine is a pure, pungent alkaloid constituent of black and long peppers (Piper nigrum and Piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated with them. In the present study, piperine was found to suppress benzo(a)pyrene (B(a)p) induced lung cancer in Swiss albino mice. In lung cancer bearing mice, altered levels of total protein and protein bound carbohydrate components (hexose, hexosamine and sialic acid) were observed in serum, lung and liver tissues. Dietary supplementation of piperine (50 mg/kg body weight) to B(a)p administered animals decreased the total protein and protein bound carbohydrate levels of lung cancer bearing animals in during initiation and post-initiation phases. Our data suggest that piperine may extend its chemopreventive effect through modulating the protein bound carbohydrate levels, as they are one of the indicators of tumorigenesis.
近年来，人们相当重视寻找新的癌症化学预防剂，这些药剂可能对人类有益。胡椒碱是黑胡椒和长胡椒（胡椒属植物）中的一种纯净、辛辣的生物碱成分，它通过与众多大分子相关联而起到抗氧化剂和抗癌剂的作用。在本研究中，发现胡椒碱可抑制苯并(a)芘（B(a)p）诱导的瑞士白化小鼠肺癌。在患有肺癌的小鼠中，观察到血清、肺和肝组织中总蛋白和蛋白结合碳水化合物成分（己糖、氨基己糖和唾液酸）水平发生改变。给经B(a)p处理的动物饮食中补充胡椒碱（50毫克/千克体重），在起始阶段和起始后阶段降低了患肺癌动物血清中总蛋白和蛋白结合碳水化合物水平。我们的数据表明，胡椒碱可能通过调节蛋白结合碳水化合物水平来扩展其化学预防作用，因为它们是肿瘤发生的指标之一。
