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Bidirectional glenn shunt surgery using lepirudin anticoagulation in an infant with heparin-induced thrombocytopenia with thrombosis.

作者信息

Iannoli Ellen D, Eaton Michael P, Shapiro Janine R

机构信息

Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, NY, USA.

出版信息

Anesth Analg. 2005 Jul;101(1):74-6, table of contents. doi: 10.1213/01.ANE.0000153019.15297.0B.

DOI:10.1213/01.ANE.0000153019.15297.0B
PMID:15976209
Abstract

There are few reports of the management of pediatric patients with heparin-induced thrombocytopenia (HIT) requiring cardiac surgery using currently available anticoagulants. We report a case of an infant with HIT requiring a bidirectional Glenn shunt who was successfully managed using lepirudin (r-hirudin, Refludan; Aventis, Bridgewater, NJ). Dosing and monitoring of anticoagulation were difficult, and we suggest caution in the use of lepirudin for cardiac surgery unless reliable monitoring of the degree of anticoagulation becomes available.

摘要

相似文献

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引用本文的文献

1
Heparin-induced thrombocytopenia in the pediatric population: a review of current literature.儿科人群中的肝素诱导的血小板减少症：当前文献综述
J Pediatr Pharmacol Ther. 2012 Jan;17(1):12-30. doi: 10.5863/1551-6776-17.1.12.
2
Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.新生儿和儿童的抗血栓治疗：抗血栓治疗和血栓预防，第 9 版：美国胸科医师学会基于证据的临床实践指南。
Chest. 2012 Feb;141(2 Suppl):e737S-e801S. doi: 10.1378/chest.11-2308.