Knoderer Chad A, Knoderer Holly M, Turrentine Mark W, Kumar Manjusha
Department of Pharmacy, Clarian Health Partners, Riley Hospital for Children, Indianapolis, IN 46202, USA.
Pharmacotherapy. 2006 May;26(5):709-12. doi: 10.1592/phco.26.5.709.
A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.
一名21个月大的男孩在接受心脏手术后接受体外膜肺氧合（ECMO）治疗，因肝素诱导的血小板减少症（HIT）接受了比伐卢定抗凝治疗。本报告阐述了心脏手术后小儿患者发生HIT的重要性以及在此情况下成功使用比伐卢定的情况。据我们所知，这是第一份关于在心脏手术和ECMO后使用比伐卢定治疗儿童HIT的发表报告。尽管有指南建议比伐卢定可能用于治疗HIT患儿，但仍需要进一步研究以确定该人群最安全且最有效的剂量。
