Dewachter Pascale, Mouton-Faivre Claudie, Tréchot Philippe, Lleu Jean-Claude, Mertes Paul Michel
Service d'anesthésie-réanimation chirurgicale Hôpital Central CHU 29 Avenue du Maréchal de Lattre de Tassigny 54035 Nancy France.
Anesth Analg. 2005 Jul;101(1):149-50, table of contents. doi: 10.1213/01.ANE.0000153497.60047.80.
We report a documented severe immunoglobulin E-mediated hypersensitivity reaction associated with use of 1% methylene blue for detection of tubal permeability occurring during general anesthesia. Clinical symptoms, biological assessment results, and cutaneous test positivity confirmed an anaphylactic reaction to methylene blue. This case report confirms the need for systematic allergological investigation of all drugs and substances administered during the perioperative period in the event of a hypersensitivity reaction occurring during anesthesia. Anesthesiologists should be aware of the possibility of hypersensitivity reactions involving any drug or substance used during surgery.
我们报告了一例有记录的严重免疫球蛋白E介导的超敏反应，该反应与在全身麻醉期间使用1%亚甲蓝检测输卵管通畅性有关。临床症状、生物学评估结果和皮肤试验阳性证实了对亚甲蓝的过敏反应。本病例报告证实，在麻醉期间发生超敏反应时，有必要对围手术期使用的所有药物和物质进行系统的变应性学调查。麻醉医生应意识到手术期间使用的任何药物或物质都可能发生超敏反应。
