Nishiyama Tomoki
Department of Anesthesiology, University of Tokyo, Japan.
Anesth Analg. 2005 Jul;101(1):242-5, table of contents. doi: 10.1213/01.ANE.0000154306.30791.F9.
We investigated the effects of IV midazolam on spinal cord blood flow in 32 cats anesthetized with isoflurane. Cats underwent laminectomy, and the lumbar spinal cord was exposed. A platinum electrode was inserted stereotaxically into the spinal cord to a depth of 1 mm-2 mm lateral to midline at L2. Arterial blood pressure, heart rate, and spinal cord blood flow (using the hydrogen clearance method) were measured before and at 5, 15, 30, 60, 90, and 120 min after an IV bolus of midazolam (0, 1, 2, or 4 mg/kg in saline 5 mL; n = 8 cats per dose). Arterial blood pressure was not affected by 0 or 1 mg/kg of midazolam but was decreased for 30 min by 2 or 4 mg/kg of midazolam. Heart rate did not change. Spinal cord blood flow was increased for 90 min by midazolam 1 mg/kg and for 15 min by midazolam 2 mg/kg but was not changed by midazolam 4 mg/kg. In conclusion, 1 mg/kg of midazolam increased feline spinal cord blood flow without changing arterial blood pressure. In contrast, a larger dose of midazolam (4 mg/kg) did not change spinal cord blood flow but substantially decreased arterial blood pressure during isoflurane anesthesia.
我们研究了静脉注射咪达唑仑对32只接受异氟烷麻醉的猫脊髓血流的影响。猫接受了椎板切除术，暴露了腰段脊髓。将一根铂电极通过立体定向插入脊髓，在L2水平距中线外侧1毫米至2毫米深处。在静脉推注咪达唑仑（在5毫升生理盐水中分别为0、1、2或4毫克/千克；每剂量n = 8只猫）之前以及之后5、15、30、60、90和120分钟测量动脉血压、心率和脊髓血流（使用氢清除法）。0或1毫克/千克的咪达唑仑对动脉血压无影响，但2或4毫克/千克的咪达唑仑可使动脉血压在30分钟内降低。心率未发生变化。1毫克/千克的咪达唑仑可使脊髓血流增加90分钟，2毫克/千克的咪达唑仑可使脊髓血流增加15分钟，但4毫克/千克的咪达唑仑对脊髓血流无影响。总之，1毫克/千克的咪达唑仑可增加猫的脊髓血流，而不改变动脉血压。相比之下，较大剂量的咪达唑仑（4毫克/千克）在异氟烷麻醉期间不会改变脊髓血流，但会显著降低动脉血压。
