Kim Dong Soon, Kim Young Sam, Jung Ki-Suck, Chang Jung Hyun, Lim Chae-Man, Lee Jae Ho, Uh Soo-Taek, Shim Jae Jeong, Lew Woo Jin
Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388-1, Poongnap-dong, Songpa-gu, Seoul, South Korea. locator="
Am J Respir Crit Care Med. 2005 Oct 1;172(7):842-7. doi: 10.1164/rccm.200502-259OC. Epub 2005 Jun 23.
Although chronic obstructive pulmonary disease is a leading cause of mortality and morbidity worldwide, there are only limited data on its prevalence, especially in Asia.
A population-based epidemiologic survey of chronic obstructive pulmonary disease in a representative national sample was conducted using spirometry.
A stratified multistage clustered probability design was used to select a nationally representative sample. The survey was performed in conjunction with the second Korean National Health and Nutrition Examination Survey of 9,243 adults over the age of 18 years. The participation rate was 88.8% for questionnaires and 52.1% for spirometry.
The prevalence of chronic obstructive pulmonary disease based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria (a ratio of FEV1 to FVC of less than 0.7) was 17.2% (men, 25.8%; women, 9.6%) among subjects older than 45 years. Among adults of all ages (age>18 years), the prevalence of airflow obstruction was 7.8% (10.9% in men, 4.9% in women). The majority of these cases were found to be mild in degree, and only a minority of these subjects had received physician diagnosis or treatment. Multivariate analysis revealed that age over 65 years, male sex, smoking more than 20 pack-years, and low income were independent predictors for chronic obstructive pulmonary disease.
Seventeen percent of Korean adults over the age of 45 years have mild chronic obstructive pulmonary disease.
尽管慢性阻塞性肺疾病是全球死亡和发病的主要原因之一，但关于其患病率的数据有限，尤其是在亚洲。
使用肺活量测定法对具有代表性的全国样本进行基于人群的慢性阻塞性肺疾病流行病学调查。
采用分层多阶段整群概率设计来选取具有全国代表性的样本。该调查与第二次韩国国民健康与营养检查调查同时进行，对象为9243名18岁以上的成年人。问卷的参与率为88.8%，肺活量测定法的参与率为52.1%。
在45岁以上的受试者中，根据慢性阻塞性肺疾病全球倡议组织（GOLD）标准（第一秒用力呼气容积与用力肺活量之比小于0.7），慢性阻塞性肺疾病的患病率为17.2%（男性为25.8%；女性为9.6%）。在所有年龄段（年龄>18岁）的成年人中，气流受限的患病率为7.8%（男性为10.9%，女性为4.9%）。这些病例中的大多数被发现程度较轻，只有少数受试者接受过医生的诊断或治疗。多变量分析显示，65岁以上、男性、吸烟超过20包年以及低收入是慢性阻塞性肺疾病的独立预测因素。
45岁以上的韩国成年人中有17%患有轻度慢性阻塞性肺疾病。
