Yoder Karmen K, Kareken David A, Seyoum Regat A, O'connor Sean J, Wang Chunzhi, Zheng Qi-Huang, Mock Bruce, Morris Evan D
Department of Radiology, Division of Research, Section of Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46206, USA.
Alcohol Clin Exp Res. 2005 Jun;29(6):965-70. doi: 10.1097/01.alc.0000171041.32716.42.
The mesolimbic dopaminergic system is thought to mediate alcohol abuse and dependence. Determining the relationship between in vivo dopamine and the subjective response to alcohol could improve understanding of the mechanisms that lead to alcohol abuse and dependence. Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion.
Nine healthy control subjects received [C]raclopride PET scanning at baseline. Eight subjects received a second [C]raclopride scan during a pharmacodynamically modeled and controlled rise of IV alcohol, followed by steady state (60 mg% +/- 5 mg%) alcohol infusion. Numerical ratings of "high" and "intoxication" were tested for correlations with measures of dopaminergic function.
Baseline D2 receptor availability in the left nucleus accumbens was significantly correlated with peak perceived "intoxication" (p = 0.02) and marginally correlated with peak perceived "high" (p = 0.07).
Resting D2 receptor availability may predict healthy subject responses to alcohol exposure.
中脑边缘多巴胺能系统被认为介导酒精滥用和依赖。确定体内多巴胺与对酒精的主观反应之间的关系，有助于增进对导致酒精滥用和依赖机制的理解。在此，我们研究了伏隔核中多巴胺D2受体与静脉输注酒精期间感知到的“兴奋”和“陶醉”评分之间的关系。
9名健康对照受试者在基线时接受[C]雷氯必利PET扫描。8名受试者在静脉酒精进行药效学建模和控制上升后，接着进行稳态（60mg%±5mg%）酒精输注期间接受第二次[C]雷氯必利扫描。对“兴奋”和“陶醉”的数字评分与多巴胺能功能指标进行相关性测试。
左侧伏隔核的基线D2受体可用性与感知到的“陶醉”峰值显著相关（p = 0.02），与感知到的“兴奋”峰值呈边缘相关（p = 0.０7）。
静息D2受体可用性可能预测健康受试者对酒精暴露的反应。
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