Guda Nalini M, Freeman Martin L, Smith Carl
Division of Gastroenterology, Hennepin County Medical Center, and University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Rev Gastroenterol Disord. 2005 Spring;5(2):73-81.
Calcifications in chronic pancreatitis are usually the result of chronic inflammation or altered metabolism. Calcifications can perpetuate the cycle of ductal obstruction and contribute to pain, worsening of pancreatic inflammation, ductal disruption, and deterioration of the exocrine and endocrine function of the gland. Removal of pancreatic duct calculi can reduce pain and improve glandular function. Purely endoscopic stone removal has limited success, because of stone location, burden, and presence of strictures in the pancreatic duct. Extracorporeal shock wave lithotripsy (ESWL) allows fragmentation of stones refractory to endoscopic methods and facilitates spontaneous stone passage or endoscopic removal. Among the various forms of lithotripters, none is clearly superior to the others. Current data suggest that ESWL is effective in complete duct clearance in up to 50% of patients and in duct decompression and symptomatic improvement in up to 70% of patients. ESWL should be considered as a useful adjunctive tool in the treatment of pancreatic duct calculi.
慢性胰腺炎中的钙化通常是慢性炎症或代谢改变的结果。钙化会使导管阻塞的循环持续存在,并导致疼痛、胰腺炎症恶化、导管破裂以及腺体的外分泌和内分泌功能恶化。去除胰管结石可减轻疼痛并改善腺体功能。单纯的内镜下取石成功率有限,这是由于结石的位置、数量以及胰管狭窄的存在。体外冲击波碎石术(ESWL)可使内镜方法难以处理的结石破碎,并促进结石自然排出或内镜下取出。在各种形式的碎石机中,没有一种明显优于其他的。目前的数据表明,ESWL在高达50%的患者中可有效实现导管完全清除,在高达70%的患者中可实现导管减压并改善症状。ESWL应被视为治疗胰管结石的一种有用的辅助工具。