Singh Santosh Kumar, Singh Rupa Dalmia, Sharma Akhilesh
Consultant Pediatric Surgeon, Diplomate of National Board, Tulsi Hospitals Ltd., 1/64 Nawabganj, Kanpur, 208002, India.
Pediatr Surg Int. 2005 Jul;21(7):578-81. doi: 10.1007/s00383-005-1451-4. Epub 2005 Jun 24.
Caudal regression syndrome is a rare disorder of distal spinal segments affecting the development of the spinal cord, with attendant sequelae. Intelligence is preserved. The exact etiology is elusive, though maternal diabetes, genetic factors, and hypoperfusion might play roles. Recently, the role of teratogens has been studied in animal models. Treatment is difficult, multidisciplinary, and largely supportive. Lower limb deformities with sensory and motor loss and neurogenic bladder call for intensive and long-term attention.
尾椎退化综合征是一种影响脊髓发育的罕见的远端脊髓节段疾病，并伴有一系列后遗症。智力不受影响。确切病因尚不清楚，不过母体糖尿病、遗传因素和灌注不足可能起作用。最近，致畸剂在动物模型中的作用已得到研究。治疗困难，需要多学科参与，且主要是支持性治疗。伴有感觉和运动丧失的下肢畸形以及神经源性膀胱需要密切和长期关注。
