Cao Xin-sheng, Sun Xi-qing, Wu Yan-hong, Wu Xing-yu, Liu Ting-song, Zhang Shu
Department of Aerospace Biodynamics, Faculty of Aviation & Aerospace, The Fourth Military Medical University, Xi'an Shannxi.
Space Med Med Eng (Beijing). 2005 Apr;18(2):79-83.
To investigate changes of learning ability and somatostatin (SS) changes after positive acceleration (+Gz) exposures.
Eighty male SD rats were randomly divided into 3 groups: control group (Con), +6 Gz/3 min group (+6 Gz), and +10 Gz/3 min group (+10 Gz), 8 rats in each group. Changes of learning ability in rats were observed at 0 d, 2 d, 4 d and 6 d after +Gz exposure. SS in hippocampus was measured by RIA at 0 d, 2 d and 4 d after +Gz exposures (there were 8 rats every time, in each group).
In Y-maze test, number of correct response decreased significantly (P<0.01), and total reaction time increased significantly (P<0.01) in +6 Gz and +10 Gz groups as compared with control group; number of correct response and total reaction time in +10 Gz group changed significantly at 0 d (P<0.01 or P<0.05) as compared with +6 Gz group. RIA showed that, content of SS in hippocampus declined at 0 d and 2 d (P<0.05 or P<0.01) in +6 Gz and +10 Gz groups as compared with control group.
+Gz exposure could impair learning ability of rats, and inhibit expression of SS in hippocampus.
探讨正向加速度（+Gz）暴露后学习能力的变化及生长抑素（SS）的变化。
80只雄性SD大鼠随机分为3组：对照组（Con）、+6 Gz/3分钟组（+6 Gz）和+10 Gz/3分钟组（+10 Gz），每组8只。在+Gz暴露后0天、2天、4天和6天观察大鼠学习能力的变化。在+Gz暴露后0天、2天和4天（每组每次8只大鼠）通过放射免疫分析法测定海马中的SS。
在Y迷宫试验中，与对照组相比，+6 Gz组和+10 Gz组的正确反应次数显著减少（P<0.01），总反应时间显著增加（P<0.01）；与+6 Gz组相比，+10 Gz组在0天时正确反应次数和总反应时间有显著变化（P<0.01或P<0.05）。放射免疫分析显示，与对照组相比，+6 Gz组和+10 Gz组在0天和2天时海马中SS的含量下降（P<0.05或P<0.01）。
+Gz暴露可损害大鼠的学习能力，并抑制海马中SS的表达。
