[+Gz暴露后大鼠胃和十二指肠中生长抑素（SS）的变化]

[Changes of somatostatin (SS) in stomach and duodenum of rats after +Gz exposure].

作者信息

Zhong Xue-jun, Wu Zhan-jun, Sun Yan-ping, Xu Gang, Xu Kui-gao, Tian Guang-qing

机构信息

Department of Gastroenterology, Jinan Shangdong, China.

出版信息

Space Med Med Eng (Beijing). 2005 Apr;18(2):148-50.

PMID:15977397

Abstract

OBJECTIVE

To study effects of +Gz exposure on the change of somatostatin (SS) in stomach and duodenum of rats.

METHOD

Forty male Wistar rats were randomly divided into +1 Gz control group, +5 Gz x 5 min group, +10 Gz x 5 min group and repeated exposure [(+5 Gz x 2 min) + (+10 Gz x 2 min) + (+5 Gz x 2 min)] group. After +Gz exposure, the rats in each group were anesthesized by aether, and gastric and duodenal mucosa were taken immediately. Levels of SS were assayed using radioimmunoassay (RIA) methods.

RESULTS

Gastric and duodenal mucosa of the control group and +5 Gz group were intact and smooth. Under naked eye and light microscope, scattered hemorrhagic spoto, small ulcers, submucosal hyperemia, and erosion of mucosa were found in gastric antrum and duodenum in +10 Gz group rats. Diffuse hyperemia, erosion and small ulcers were found in mucosa of gastric fundus, gastric antrum and duodenum of repeated exposure group. Exposure to +Gz can increase somatostatin content in gastric antrum and duodenum (P<0.01).

CONCLUSION

Increase of SS content may play an important role in the prevention of pathogenesis of stomach and duodenum after +G exposure.

摘要

目的

研究 +Gz 暴露对大鼠胃和十二指肠中生长抑素（SS）变化的影响。

方法

将 40 只雄性 Wistar 大鼠随机分为 +1 Gz 对照组、+5 Gz×5 分钟组、+10 Gz×5 分钟组和重复暴露组[（+5 Gz×2 分钟）+（+10 Gz×2 分钟）+（+5 Gz×2 分钟）]。+Gz 暴露后，每组大鼠用乙醚麻醉，立即取胃和十二指肠黏膜。采用放射免疫分析（RIA）法检测 SS 水平。