模拟失重暴露后大鼠血清及某些组织中内源性哇巴因的变化
[Changes of endogenous ouabain in rat serum and certain tissues after exposure to simulated weightlessness].
作者信息
Liu Zhao-xia, Gao Guang-dao, Hu Yong-jie, Wang De-sheng, WU Da-wei, Yuan Ming, Li Zhi-li
机构信息
Department of Medicine, Xi'an Jiaotong University, Xi'an Shannxi, China.
出版信息
Space Med Med Eng (Beijing). 2005 Apr;18(2):94-7.
OBJECTIVE
To investigate the changes of endogenous ouabain (EO) in rat serum and some tissues after exposure to simulated weightlessness and to investigate its possible pathophysiology.
METHOD
Male Wistar rats were randomly divided into control group (Con) and 1 week tail-suspension group (TS). Enzyme-linked immunosorbent assay (ELISA) was used to detect the content of EO in serum, hypothalamus, pituitary, adrenal gland, kidney, heart and liver.
RESULT
Compared with Con, EO increased significantly in serum, hypothalamus, adrenal gland and kidney after tail suspension (P<0.05).
CONCLUSION
Simulated weightlessness induced changes of EO in serum and some tissues, which may have some effects on the regulation of hydro-electrolyte metabolism and cardiovascular functions.
目的
研究模拟失重后大鼠血清及某些组织中内源性哇巴因（EO）的变化，并探讨其可能的病理生理学机制。
方法
雄性Wistar大鼠随机分为对照组（Con）和尾部悬吊1周组（TS）。采用酶联免疫吸附测定（ELISA）法检测血清、下丘脑、垂体、肾上腺、肾脏、心脏和肝脏中EO的含量。
结果
与Con组相比，尾部悬吊后血清、下丘脑、肾上腺和肾脏中的EO显著升高（P<0.05）。
结论
模拟失重可引起血清及某些组织中EO的变化，这可能对水电解质代谢和心血管功能的调节产生一定影响。
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