Joray S, Ghika J, von Gunten A, Büla C, Gold G, Assal F
Service de neurologie, CHUV, Lausanne.
Rev Med Suisse. 2005 May 4;1(18):1201-2, 1205-6, 1208.
Alzheimer's disease is a frequent neurodegenerative disease, which affects more than one third of elderly persons over 80 years. No curative treatment is currently available for this disease, but symptomatic treatments have produced significant improvements in patients' condition. Cholinesterase inhibitors should be prescribed for early and moderate stages and memantine for more severe stages of the disease. These drugs have an impact on cognitive performances, may delay functional decline and improve behaviour disturbances. From a preventive perspective, evidence of benefit from early management of vascular risk factors is accumulating. In the near future, the improved comprehension of the underlying mechanisms of Alzheimer's disease will hopefully bring new treatments, thats will delay or modify its course.
阿尔茨海默病是一种常见的神经退行性疾病，影响超过三分之一的80岁以上老年人。目前尚无针对该疾病的治愈性治疗方法，但对症治疗已使患者病情有显著改善。胆碱酯酶抑制剂应在疾病早期和中期使用，美金刚用于疾病更严重阶段。这些药物对认知能力有影响，可能延缓功能衰退并改善行为障碍。从预防角度来看，越来越多的证据表明早期管理血管危险因素有益。在不久的将来，对阿尔茨海默病潜在机制的深入理解有望带来新的治疗方法，从而延缓或改变其病程。
