Fayerweather W E, Karns M E, Gilby P G, Chen J L
E.I. du Pont de Nemours Company, Wilmington, DE 19898.
J Occup Med. 1992 Feb;34(2):164-9. doi: 10.1097/00043764-199202000-00017.
A study was done to examine whether workers exposed to titanium tetrachloride had significantly higher risks of lung cancer, chronic respiratory disease, pleural thickening/plaques, or pulmonary fibrosis than referent groups. A total of 2477 employees from two titanium dioxide plants were studied. Of that group, 969 employees exposed to titanium tetrachloride were observed from 1956 through 1985 for cancer and chronic respiratory disease incidence and from 1935 through 1983 for mortality. A cross-sectional sample of 398 employees was evaluated for chest roentgenogram abnormalities. Cohort analyses showed that the risk of developing lung cancer and other fatal respiratory diseases was not statistically significantly higher for the titanium tetrachloride-exposed workers than for the referent group. Nested case-control analyses found no statistically significant association between titanium tetrachloride exposure and risk of lung cancer, chronic respiratory disease, and chest roentgenogram abnormalities. No cases of pulmonary fibrosis were observed among titanium tetrachloride-exposed employees. Smoking was found to be a strong predictor of lung cancer mortality in the nonexposed employees with an increased risk of dying from lung cancer up to 7-fold higher in current smokers than in nonsmokers.
一项研究旨在检验接触四氯化钛的工人患肺癌、慢性呼吸道疾病、胸膜增厚/斑块或肺纤维化的风险是否显著高于对照组。对两家二氧化钛工厂的2477名员工进行了研究。在该组中，对969名接触四氯化钛的员工从1956年至1985年进行了癌症和慢性呼吸道疾病发病率观察，并从1935年至1983年进行了死亡率观察。对398名员工的横断面样本进行了胸部X光片异常评估。队列分析表明，接触四氯化钛的工人患肺癌和其他致命呼吸道疾病的风险在统计学上并不显著高于对照组。巢式病例对照分析发现，四氯化钛暴露与肺癌、慢性呼吸道疾病和胸部X光片异常风险之间无统计学显著关联。在接触四氯化钛的员工中未观察到肺纤维化病例。研究发现，吸烟是未接触员工肺癌死亡率的一个强有力预测因素，当前吸烟者死于肺癌的风险比不吸烟者高出7倍。
