Chen J L, Fayerweather W E
E. I. Du Pont de Nemours and Company, Inc., Medical Division, Wilmington, DE 19898.
J Occup Med. 1988 Dec;30(12):937-42. doi: 10.1097/00043764-198812000-00011.
The objective of this study was to determine whether workers exposed to titanium dioxide (TiO2) had significantly higher risks of lung cancer, chronic respiratory disease, pleural thickening/plaques, or pulmonary fibrosis than referent groups. A total of 1,576 employees exposed to TiO2 were observed from 1956 through 1985 for cancer and chronic respiratory disease incidence, and from 1935 through 1983 for mortality. A cross-sectional sample of 398 employees was evaluated for chest roentgenogram abnormalities. Cohort analyses suggested that the risks of developing lung cancer and other fatal respiratory diseases were no higher for TiO2-exposed employees than for the referent groups. Nested case-control analyses found no statistically significant associations between TiO2 exposure and risk of lung cancer, chronic respiratory disease, and chest roentgenogram abnormalities. No cases of pulmonary fibrosis were observed among TiO2-exposed employees.
本研究的目的是确定接触二氧化钛（TiO₂）的工人患肺癌、慢性呼吸道疾病、胸膜增厚/斑块或肺纤维化的风险是否显著高于参照组。从1956年至1985年观察了总共1576名接触TiO₂的员工的癌症和慢性呼吸道疾病发病率，并从1935年至1983年观察了他们的死亡率。对398名员工的横断面样本进行了胸部X光片异常评估。队列分析表明，接触TiO₂的员工患肺癌和其他致命呼吸道疾病的风险并不高于参照组。巢式病例对照分析未发现TiO₂暴露与肺癌、慢性呼吸道疾病和胸部X光片异常风险之间存在统计学上的显著关联。在接触TiO₂的员工中未观察到肺纤维化病例。
