DiBaise John K
Mayo Clinic Scottsdale, Scottsdale, Arizonia, USA.
Pharmacotherapy. 2005 Apr;25(4):620-5. doi: 10.1592/phco.25.4.620.61032.
Tegaserod, a potent partial agonist of the serotonin 5-HT4 receptor, is used to treat women with constipation-predominant irritable bowel syndrome. Since the drug's approval, the manufacturer has received infrequent although serious reports of diarrhea and ischemic colitis in patients taking the drug. These instances have led to a recent warning letter to physicians and a change in the prescription labeling of tegaserod. We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome. Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.
替加色罗是一种强效的5-羟色胺5-HT4受体部分激动剂，用于治疗以便秘为主的肠易激综合征女性患者。自该药物获批以来，尽管服用该药物的患者出现腹泻和缺血性结肠炎的严重报告并不常见，但制造商仍收到了此类报告。这些病例导致近期向医生发出了警告信，并对替加色罗的处方标签进行了修改。我们描述了一名接受替加色罗治疗的女性发生缺血性结肠炎的过程，并回顾了缺血性结肠炎、替加色罗使用与肠易激综合征之间的关系。还讨论了接受替加色罗治疗的患者发生缺血性结肠炎的潜在机制。
