McLeod Sarah M, Kimsey Harvey H, Davis Brigid M, Waldor Matthew K
Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Mol Microbiol. 2005 Jul;57(2):347-56. doi: 10.1111/j.1365-2958.2005.04676.x.
The genes encoding cholera toxin, one of the principal virulence factors of the diarrhoeal pathogen Vibrio cholerae, are part of the genome of CTXphi, a filamentous bacteriophage. Thus, CTXphi has played a critical role in the evolution of the pathogenicity of V. cholerae. Unlike the well-studied F pilus-specific filamentous coliphages, CTXphi integrates site-specifically into its host chromosome and forms stable lysogens. Here we focus on the CTXphi life cycle and, in particular, on recent studies of the mechanism of CTXphi integration and the factors that govern lysogeny. These and other processes illustrate the remarkable dependence of CTXphi on host-encoded factors.
编码霍乱毒素（腹泻病原体霍乱弧菌的主要毒力因子之一）的基因是丝状噬菌体CTXphi基因组的一部分。因此，CTXphi在霍乱弧菌致病性的进化过程中发挥了关键作用。与研究充分的F菌毛特异性丝状大肠杆菌噬菌体不同，CTXphi以位点特异性方式整合到其宿主染色体中并形成稳定的溶原菌。在这里，我们重点关注CTXphi的生命周期，特别是最近关于CTXphi整合机制以及控制溶原性的因素的研究。这些以及其他过程说明了CTXphi对宿主编码因子的显著依赖性。
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